Breast Cancer History Lowers Accuracy of Mammogram

Mammogram's sensitivity lower in the initial five-year period after the first cancer

TUESDAY, Feb. 22 (HealthDay News) -- Mammography screening for breast cancer may be less accurate among women with a personal history of breast cancer (PHBC), despite a higher underlying cancer rate, relative to women without PHBC, according to a study published in the Feb. 23 issue of the Journal of the American Medical Association.

Nehmat Houssami, M.B.B.S., Ph.D., of the University of Sydney in Australia, and colleagues investigated the accuracy of mammography breast cancer screening among women with PHBC. They studied screening mammograms in women with and without a history of early-stage breast cancer and calculated the accuracy of the screening test (based on the scan's final assessment), the cancer detection rate, the interval cancer rate, and the stage at diagnosis.

The researchers found that, despite higher rates of cancer, cancer detection, and interval cancer, the mammogram's sensitivity was significantly lower among PHBC women compared to non-PHBC women (65.4 versus 76.5 percent). Screening sensitivity and detection was higher for in-situ tumors compared to invasive cancer in PHBC women. Among the PHBC women, the mammogram's sensitivity was lower in the initial five-year period after the first cancer, and subsequently increased. Most of the cancers detected in both groups of women were at the early stage.

"Screening mammography detects early-stage breast cancers in PHBC women but has lower accuracy relative to screening women without PHBC. Despite a relatively high interval cancer rate, interval cancers in PHBC women had generally favorable stage distributions," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

Featured Jobs



Benefits of Membership

FREE E-Newsletters
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues

CESaver
Join our CESaver program to earn up to 100 contact hours for only $34.95
Register Now

Lippincott's NursingCenter.com
Explore a world of online resources

Become a Member