Link Found Between Cognitive Function, Neighborhood

Psychosocially hazardous area may negatively affect functioning in those with genetic variant

TUESDAY, March 8 (HealthDay News) -- Growing old in a psychosocially hazardous neighborhood may have a diminishing effect on cognitive functioning in people with the ε4 variant of the apolipoprotein E (APOE) gene, according to research published in the March issue of the Archives of General Psychiatry.

To study whether the APOE ε4 allele modifies the influence of neighborhood characteristics on cognitive function, Brian K. Lee, Ph.D., of the Drexel University School of Public Health in Philadelphia, and colleagues measured cognitive performance in 1,140 urban residents 50 to 70 years old in 65 Baltimore neighborhoods that had been characterized by psychosocial environment.

After fully adjusting for individual covariates, the researchers found no consistent association between high neighborhood psychosocial hazards and worse cognitive performance in general, but there was an association between the two in people with the APOE ε4 genotype. Specifically, they found evidence of associations in processing speed and executive functioning. They found suggestive evidence for eye-hand coordination (P = .05).

"Living in a psychosocially hazardous neighborhood was associated with worse cognitive function in persons with the APOE ε4 allele, evidence of a novel gene X environment interaction," the authors write.

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events