Depression Linked to Adverse Renal Disease Outcomes

Depressive symptoms independently associated with increased risk of acute kidney injury

FRIDAY, March 11 (HealthDay News) -- Symptoms of depression are associated with subsequent adverse outcomes in patients with renal disease, according to a study published online March 10 in the Clinical Journal of the American Society of Nephrology.

Willem J. Kop, Ph.D., from the University of Maryland in Baltimore, and colleagues determined the association of depressive symptoms with decline in renal function, new-onset chronic kidney disease (CKD), end-stage renal disease (ESRD), or hospitalization with acute kidney injury (AKI). Depressive symptoms were measured in 5,785 patients using the 10-item Centers for Epidemiologic Studies Depression scale. Renal function was measured during an average follow-up of 10.5 years.

The researchers found that depressed participants had a higher prevalence of CKD at baseline compared to those participants who were not depressed. Unadjusted models linked depression with a subsequent risk of rapid decline in estimated glomerular filtration rate, incident ESRD, and AKI. In multivariable analyses after adjusting for traditional renal disease risk factors, the only remaining significant association was that of depressive symptoms with AKI.

"The association of depressive symptoms with long-term risk of AKI is independent of a broad range of covariates and therefore clinically important," the authors write. "These findings show that the association between depression with adverse renal outcomes is not merely an epiphenomenon of underlying symptomatic renal disease."

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