Artesunate Provides Superior Treatment for Severe Malaria

More effective than standard quinine treatment for both children and adults

FRIDAY, March 18 (HealthDay News) -- Treatment of severe malaria with artesunate is superior to quinine for both adults and children, according to a review published in the Cochrane Database of Systematic Reviews.

David Sinclair, B.M.B.Ch., from the Liverpool School of Tropical Medicine in the United Kingdom, and colleagues compared artesunate with quinine for the treatment of severe malaria. Literature searches identified eight randomized controlled trials comparing intravenous, intramuscular, or rectal artesunate treatment with intravenous or intramuscular quinine in 1,664 adults and 5,765 children who were unable to take oral medications. The primary outcome measured was all-cause death.

The investigators found that artesunate treatment significantly reduced the risk of mortality for adults and children (relative risks, 0.61 and 0.76, respectively). An increase in the incidence of neurological sequelae was seen in children treated with artesunate, but the majority were transient, and there was no significant difference at follow-up 28 days later.

"There is now adequate evidence to be confident of the results in both adults and children," the authors write. "Intravenous artesunate should be the treatment of choice for adults and children presenting with severe malaria in any geographical region."

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events