View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, March 18 (HealthDay News) -- A transanal submucosal injection of dextranomer in stabilized hyaluronic acid (NASHA Dx) is an effective treatment for fecal incontinence, according to a study published in the March 19 issue of The Lancet.
Wilhelm Graf, Ph.D., from the Akademiska Sjukhuset in Uppsala, Sweden, and colleagues assessed the efficacy of transanal submucosal injections of NASHA Dx for the treatment of fecal incontinence. Of the 206 patients, aged 18 to 75 years, with fecal incontinence who were included in the study, 136 were randomly assigned to receive transanal submucosal injections of NASHA Dx and 70 received sham. The severity of fecal incontinence and quality of life were assessed at six months by clinical assessments and patient diaries. A 50 percent or greater reduction in the number of incontinence episodes was the primary end point of the study. Patients in the active treatment group were still being followed up at the time of publication.
The investigators found that 52 percent of patients who received NASHA Dx experienced a 50 percent or more reduction in the number of incontinence episodes compared to 31 percent of patients who received sham treatment (odds ratio, 2.36). A total of 128 treatment-related adverse events were recorded, including one rectal abscess and one prostatic abscess, both of which were serious.
"Submucosal injection of NASHA Dx provided a substantial improvement in incontinence symptoms when compared with baseline and with sham treatment," the authors write.
Several authors disclosed financial relationships with Q-Med AB, which funded the study.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top