Progesterone Gel Linked With Lower Rate of Preterm Birth

Gel reduces the frequency of preterm birth in women with sonographically short cervix lengths

WEDNESDAY, April 20 (HealthDay News) -- Administration of vaginal progesterone gel in women with a sonographically short cervix in the second trimester is correlated with a significant reduction in the rate of preterm birth, according to a study published online April 6 in Ultrasound in Obstetrics & Gynecology.

Sonia S. Hassan, M.D., from the Eunice Kennedy Shriver National Institute of Child Health and Human Development in Bethesda, Md., and colleagues investigated the efficacy and safety of micronized vaginal progesterone gel for reducing the risk of preterm birth and its related complications in women with a sonographically short cervix (10 to 20 mm). Asymptomatic women with a singleton pregnancy were randomized to receive vaginal progesterone gel (235 women) or placebo (223 women) every day starting from 20 to 23 weeks and six days, until 36 weeks and six days, membrane rupture, or delivery.

The researchers found that women in the vaginal progesterone group had a significantly lower rate of preterm birth before 33 weeks compared to those in the placebo group (relative risk [RR], 0.55). This effect persisted after adjusting for confounders. Vaginal progesterone was also correlated with a significantly reduced rate of preterm birth before 28 and 35 weeks (RR, 0.50 and 0.62, respectively). Respiratory distress syndrome, neonatal morbidity or mortality events, and birth weight less than 1,500 g were all significantly lower in the vaginal progesterone group.

"Universal screening of women with transvaginal cervical length in the midtrimester to identify patients at risk can now be coupled with an intervention -- the administration of vaginal progesterone gel -- to reduce the frequency of preterm birth and improve neonatal outcome," the authors write.

Several of the study authors disclosed financial relationships with Columbia Laboratories Inc., which partially funded the study. One of the study authors holds a patent for use of progesterone in the prevention of preterm birth.

Full Text

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events