Bone measurement may be better predictor than BMI of insulin resistance in obese children
TUESDAY, April 12 (HealthDay News) -- Measurement of wrist circumference in obese adolescents may be a better indicator of insulin resistance than standard deviation score body mass index (BMI), according to a study published online April 11 in Circulation.
Marco Capizzi, M.D., from the University "Sapienza" in Rome, and colleagues evaluated manual measure of wrist circumference and standard deviation score BMI, fasting biochemical parameters, and homeostasis model assessment of insulin resistance in 477 obese children (mean age, 10.31±2.80 years), to find an easy-to-detect clinical marker of insulin resistance (used to detect the risk of cardiovascular disease). Nuclear magnetic resonance (NMR) imaging of the wrist was performed on 51 randomly selected children to evaluate transversal wrist area at the Lister tubercle level.
The investigators identified a significant correlation between wrist circumference and insulin levels or homeostasis model assessment of insulin resistance. The correlation was more significant than that seen between standard deviation score BMI and insulin levels or the homeostasis model. Based on NMR imaging, the correlation between wrist circumference and insulin levels or the homeostasis model was demonstrated to be association with bone tissue-related areas, and not the adipose tissue.
"Our findings suggest a close relationship among wrist circumference, its bone component, and insulin resistance in overweight/obese children and adolescents, opening new perspectives in the prediction of cardiovascular disease," the authors write.
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