Residual Depressive Symptoms in Responders to Citalopram

Depressed patients who respond to citalopram but don't remit report residual depressive symptoms

MONDAY, May 9 (HealthDay News) -- Patients with major depressive disorder (MDD) who respond to citalopram but do not remit report a range of residual domains and depressive symptoms, according to a study published in the April issue of the Journal of Clinical Psychopharmacology.

Shawn M. McClintock, Ph.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues investigated the residual domains and individual depressive symptoms in a large sample of outpatients with nonpsychotic MDD who responded to treatment of up to 12 weeks of citalopram without remitting. Response was defined as a 50 percent or greater reduction in baseline 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16) by the completion of treatment, and remission was defined as a final QIDS-SR16 score lower than six. Residual domains and individual symptoms were classified as persisting from baseline or developing during treatment.

The investigators found that most responders who did not remit reported five domains, most commonly insomnia, sad mood, and decreased concentration. They also reported six to seven residual depressive symptoms, most frequently midnocturnal insomnia and decreased general interest. The most frequent lasting symptoms were midnocturnal insomnia, sad mood, and decreased concentration or decision making. The least common persistent residual and treatment emergent symptom was suicidal ideation.

"Patients with nonpsychotic MDD who achieved response but not remission with citalopram experienced substantial residual depressive symptoms," the authors write. "It seems important to differentiate symptoms that emerge during treatment from those that persist from baseline to exit, as this distinction may well have implications for guiding treatment."

Several of the study authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events