Oophorectomy May Not Adversely Affect Health

Also tied to lower risk of ovarian cancer than hysterectomy plus ovarian conservation

WEDNESDAY, April 27 (HealthDay News) -- Elective bilateral salpingo-oophorectomy (BSO) with hysterectomy is associated with a lower risk of ovarian cancer than ovarian conservation and hysterectomy, and BSO does not appear to have adverse effects on cardiovascular health, hip fracture, cancer, or total mortality compared with ovarian conservation and hysterectomy, according to research published in the April 25 issue of the Archives of Internal Medicine.

To examine the effect of BSO on incident cardiovascular disease, hip fracture, cancer, and death, Vanessa L. Jacoby, M.D., of the University of California in San Francisco, and colleagues studied women aged 50 to 79 with a history of hysterectomy and BSO (14,254) or hysterectomy and ovarian conservation (11,194) and no family history of ovarian cancer.

The researchers found no association between BSO and cardiovascular disease, hip fracture, or death. Incident ovarian cancer was lower in the BSO group than in the ovarian conservation group (0.02 percent compared with 0.33 percent), but no significant associations were found for breast, colorectal, or lung cancer.

"Our negative findings for BSO risk do not indicate that ovarian hormones lack an important role in the pathogenesis of cardiovascular health, fractures, cancer, or death. Rather, our results suggest that, compared with women who undergo hysterectomy alone, concomitant BSO may not incur additional risks," the authors write.

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