NKF: Gender Plays Role in Angiogram Kidney Damage

Radiocontrast-induced nephropathy seen more often in women than men

THURSDAY, April 28 (HealthDay News) -- Women are more likely than men to experience kidney damage after undergoing a coronary angiogram, according to research presented at the National Kidney Foundation's Spring Clinical Meeting, held from April 26 to 30 in Las Vegas.

Javier Neyra, M.D., of Henry Ford Hospital in Detroit, and colleagues studied data on 1,211 patients who underwent coronary angiography to assess risk factors for and investigate the role of gender in developing radiocontrast-induced nephropathy (RCIN) after the procedure.

Defining RCIN as an increase of more than 25 percent in creatinine from baseline, an absolute increase in creatinine of at least 0.5 mg/dL, or a decrease in estimated glomerular filtration rate of at least 25 percent within 72 hours after contrast exposure, the team determined female sex was an independent predictor of RCIN, which occurred in 19.8 percent of the women and 13.6 percent of the men. Other predictors of RCIN were use of furosemide and contrast media volume.

"Because men and women patients receive the same amount of dye during a coronary angiogram, it's possible the amount is just too much for a woman's body to handle given her smaller size," Neyra said in a statement. "Perhaps a woman's height and weight ought to be factored into the dosage."

Abstract - Page 32
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