L-Arginine Linked to Decreased Pre-Eclampsia Risk

Supplementation with L-arginine and antioxidants decreases the risk for high-risk women

FRIDAY, May 20 (HealthDay News) -- The risk of pre-eclampsia may be reduced by dietary supplementation with both L-arginine and antioxidant vitamins in high-risk women, according to a study published online May 19 in BMJ.

Felipe Vadillo-Ortega, M.D., Ph.D., from the National Autonomous University of Mexico in Mexico City, and colleagues investigated whether relative deficiency of L-arginine is associated with development of pre-eclampsia in 672 high-risk pregnant women. Participants had either a positive history of pre-eclampsia in previous pregnancy, or a first-degree relative with pre-eclampsia, and were considered to be high risk. They were followed up from 14 to 32 weeks of gestation until delivery. A total of 228 participants were randomly allocated to receive bars containing L-arginine plus antioxidant vitamins, 222 participants received bars of antioxidant vitamins alone, and 222 were allocated to placebo. Development of pre-eclampsia or eclampsia was the main outcome studied.

The investigators found that, compared to the placebo group, participants receiving L-arginine plus antioxidant vitamins showed a significant decrease in pre-eclampsia risk (absolute risk reduction, 0.17), while the antioxidant vitamins-alone group showed a slight decrease in pre-eclampsia risk (absolute risk reduction 0.07; P = 0.052). Compared to the antioxidant vitamins-alone group, the L-arginine plus antioxidant vitamins group experienced a significant pre-eclampsia risk reduction (absolute risk reduction, 0.09).

"We observed a significant reduction in the incidence of pre-eclampsia/eclampsia in pregnant women who consumed bars containing L-arginine plus antioxidant vitamins. The results of this trial support the proposed hypothesis that supplemental L-arginine can reduce the risk of pre-eclampsia," the authors write.

Abstract
Full Text

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events