Polypills May Reduce Blood Pressure and LDL Cholesterol

Considerable side effects observed, but most are mild and do not warrant therapy cessation

THURSDAY, May 26 (HealthDay News) -- Use of combination cardiovascular medications, or polypills, is associated with significant reductions in systolic blood pressure (SBP) and low-density lipoprotein (LDL) cholesterol, according to a study published online May 25 in PLoS One.

Anthony Rodgers, M.B.Ch.B., Ph.D., from the George Institute for Global Health in Sydney, Australia, and colleagues from the Program to Improve Life and Longevity Collaborative Group investigated the effectiveness and tolerability of polypills containing 75 mg aspirin, 10 mg lisinopril, 12.5 mg hydrochlorothiazide, and 20 mg simvastatin. The investigators randomly assigned 378 individuals with an estimated five-year cardiovascular risk of over 7.5 percent, but without an indication for any component of the polypill to treatment with polypill or placebo. The changes in SBP, LDL cholesterol, and tolerability (measured as the proportion who discontinued randomized therapy) were evaluated at a 12-week follow-up.

The investigators found that, with polypill use, SBP was significantly reduced by 9.9 mm Hg, from 134 mm Hg at baseline, and LDL cholesterol was significantly reduced by 0.8 mmol/L, from 3.7 mmol/L at baseline. Treatment discontinuation rates were similar in the polypill and placebo groups (23 and 18 percent, respectively). Side effects of component medicines were seen in significantly more participants from the polypill group than the placebo group (58 versus 42 percent), but these were mostly mild and did not necessitate treatment cessation.

"These results show that treatment with this polypill achieved sizeable reductions in SBP and LDL cholesterol. These risk-factor reductions, together with the findings of systematic reviews of the component medicines, indicate that this treatment can be expected to more than halve cardiovascular risk," the authors write.

Polypills and placebo were provided free-of-charge by Dr. Reddy's Laboratories.

Full Text

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events