Perinatal Exposures May Impact Breast Development

Endocrine-disrupting chemicals may affect breast development and lactation, increase cancer risk

WEDNESDAY, June 22 (HealthDay News) -- Gestational or perinatal exposure to certain endocrine-disrupting chemicals (EDCs) can alter mammary gland (MG) development, disrupt lactation, and increase susceptibility to breast cancer, according to a review published online June 22 in Environmental Health Perspectives.

Julia Green Brody, Ph.D., from the Silent Spring Institute in Newton, Mass., and colleagues reported the current science, public health issues, and research recommendations for evaluating MG development. They integrated the views of 18 experts who participated in the Mammary Gland Evaluation and Risk Assessment Workshop, held in November 2009, in Oakland, Calif. The effects of gestational or perinatal exposure to EDCs on MG development, lactation, and cancer; relative sensitivity of MG and other developmental end points; relevance of animal models to humans; and methods for evaluating MG effects were discussed.

The investigators reported that there are temporal, morphological, and mechanistic similarities between test animal species and humans with respect to normal MG development and MG carcinogenesis. MG development in rodents is affected by diverse chemicals, including those that are not considered primarily estrogenic. Comparison across studies was hindered by inconsistent reporting methods: Some studies were still defining the relationships between altered development and effects on lactation or carcinogenesis, while other studies were reporting altered MG development as the most sensitive endocrine end point. Research recommendations include assessing the relationship between MG development and lactation and cancer, and chemical toxicity testing and risk assessment.

"Early life environmental exposures can alter MG development, disrupt lactation, and increase susceptibility to breast cancer. Assessment of MG development should be incorporated in chemical test guidelines and risk assessment," the authors write.

Full Text

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events