Varenicline Use Linked to Adverse Cardiovascular Events

Increased risk of serious adverse cardiovascular events with varenicline use for tobacco users

TUESDAY, July 5 (HealthDay News) -- Use of the smoking-cessation drug varenicline is associated with an increase in the risk of serious adverse cardiovascular events among tobacco users, according to a meta-analysis published online July 4 in CMAJ, the journal of the Canadian Medical Association.

Sonal Singh, M.D., M.P.H., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues reviewed available literature from September 2010 to March 2011 to compare and assess the risk of serious adverse cardiovascular events between varenicline and placebo among tobacco users. A total of 14 randomized controlled trials (RCTs), involving 8,216 participants (smokers or people who used smokeless tobacco), and varying between seven to 52 weeks in duration, were included in the analysis. The RCTs reported cardiovascular events (ischemia, arrhythmia, congestive heart failure, sudden death, or cardiovascular-related death) as serious adverse events linked to the use of varenicline.

The investigators found that compared with placebo, varenicline use was associated with a significantly increased risk of serious adverse cardiovascular events (0.82 percent in placebo group and 1.06 percent in varenicline; odds ratio, 1.72). The results from several sensitivity analyses and those of the main analysis were consistent and there was no publication bias. Meaningful comparisons of mortality could not be done due to the low number of deaths.

"Our meta-analysis raises safety concerns about the potential for an increased risk of serious adverse cardiovascular events associated with the use of varenicline among tobacco users," the authors write.

One of the study authors disclosed financial ties to Pfizer.

Abstract
Full Text
Editorial (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events