View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, July 5 (HealthDay News) -- Prenatal use of selective serotonin reuptake inhibitors (SSRIs), especially during the first trimester of pregnancy, may increase the risk of autism spectrum disorders (ASDs) in children, according to a study published online July 4 in the Archives of General Psychiatry.
Lisa A. Croen, Ph.D., from Kaiser Permanente Northern California in Oakland, and colleagues investigated the association between prenatal use of antidepressants and the risk of ASDs in children. Data were collected from 298 children with ASDs (cases) and 1,507 randomly selected controls, and their respective mothers, on mothers' use of antidepressant medication, mental health of the mothers, and demographic and medical covariates.
The investigators identified 20 (6.7 percent) cases and 50 (3.3 percent) control children who were exposed to antidepressant medication prenatally. Treatment of mothers with SSRIs, one year before delivery, was associated with a two-fold increased risk of ASD (adjusted odds ratio, [OR], 2.2), with treatment in the first trimester showing the strongest association (adjusted OR, 3.8). Children born to mothers with a history of mental health treatment but no prenatal exposure to SSRIs did not show an increased risk.
"Our results suggest that prenatal exposure to SSRIs, especially during the first trimester, may modestly increase the risk of ASDs," the authors write.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top