View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, July 18 (HealthDay News) -- Statin therapy is not associated with a significant increase in cancer risk in older U.S. adults, according to a study published in the July 26 issue of the Journal of the American College of Cardiology.
Claudio Marelli, M.D., from S² Statistical Solutions Inc. in Cincinnati, and colleagues investigated whether cancer can be attributed to statin use in a population of older U.S. adults. Records for more than 11 million patients were extracted from the General Electric Centricity electronic medical records database from 1990 through 2009. Propensity matching was used to identify pairs of patients who shared similar propensities for statin use, and who were receiving and not receiving statin therapy. A total of 45,857 pairs were identified and followed up for an average of 4.7 years (those receiving statins) and 4.6 years (those not receiving statins).
The investigators found that, after matching, the incidence of cancer in patients taking and not taking a statin was found to be 11.37 and 11.11 percent, respectively (hazard ratio, 1.04; 95 percent confidence interval, 0.99 to 1.09). There was no difference seen in Kaplan-Meier curves for diagnosis of any cancer up to 10 years for patients taking and not taking a statin.
"This retrospective database analysis of a general population of 45,857 matched pairs of patients with an average of 4.6 years of follow-up after time zero revealed no statistically significant association of statins with cancer," the authors write.
Several authors disclosed financial relationships with health care, technology, and research institutes.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top