Chinese Herbal Decoction Cuts Time to H1N1 Fever Resolution

Maxingshigan-yinqiaosan effective alone and in combination with oseltamivir

TUESDAY, Aug. 16 (HealthDay News) -- Chinese herbal decoction maxingshigan-yinqiaosan, alone or in combination with oseltamivir, is associated with a reduced time to fever resolution in patients with H1N1 influenza virus infection, according to a study published in the Aug. 16 issue of the Annals of Internal Medicine.

Chen Wang, M.D., Ph.D., from the Ministry of Health in Beijing, and colleagues compared the efficacy and safety of maxingshigan-yinqiaosan with oseltamivir for the treatment of uncomplicated H1N1 influenza. A total of 410 adults between the ages of 15 and 59 years with confirmed H1N1 influenza received either oseltamivir (75 mg twice daily) alone, a decoction of maxingshigan-yinqiaosan (200 mL, four times daily), oseltamivir plus maxingshigan-yinqiaosan, or no treatment (control) for a period of five days. Time to fever resolution was the primary outcome measure, and symptom scores and viral shedding using real-time reverse transcriptase polymerase chain reaction were the secondary outcome measures.

The investigators found that oseltamivir (34 percent), maxingshigan-yinqiaosan (37 percent), and the combination treatment of oseltamivir plus maxingshigan-yinqiaosan (47 percent) significantly reduced the median time to fever resolution compared to the control group. The combination treatment reduced time to fever resolution by 19 percent when compared to oseltamivir alone. The decrease in symptom scores was not significantly different in the intervention or control groups. Nausea and vomiting were reported in two patients receiving maxingshigan-yinqiaosan.

"Oseltamivir and maxingshigan-yinqiaosan, alone and in combination, reduced time to fever resolution in patients with H1N1 influenza virus infection," the authors write.

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