Diastolic Dysfunction Ups Heart Failure Risk in Elderly

Diastolic dysfunction is prevalent, worsens over time, and is associated with increasing age

WEDNESDAY, Aug. 24 (HealthDay News) -- Left ventricular diastolic dysfunction worsens over time and with advancing age, increasing the risk of subsequent heart failure, according to a study published in the Aug. 24/31 issue of the Journal of the American Medical Association.

Garvan C. Kane, M.D., Ph.D., from the Mayo Clinic and Medical School in Rochester, Minn., and colleagues investigated changes in diastolic function over time, and assessed the relationship between diastolic dysfunction and the risk of heart failure in 2,042 patients aged 45 years or older. Examination (1997 to 2000) included clinical evaluation, medical record abstraction, and echocardiography, and diastolic left ventricular function was graded as normal, mild, moderate, or severe. After four years, 1,402 participants returned for examination 2 (2001 to 2004) and were followed up for new-onset heart failure (2004 to 2010). Changes in diastolic function grade and incident heart failure were the outcomes measured.

The investigators found that between the time of examinations 1 and 2, the prevalence of diastolic dysfunction increased significantly from 23.8 to 39.2 percent. For 23.4 percent of the patients diastolic function grade worsened, for 67.8 percent it was unchanged, and for 8.8 percent it improved. Worse diastolic function was correlated with being ≥ 65 years of age (odds ratio, 2.85). During follow-up after examination 2, heart failure incidence was seen in 2.6 percent of the patients whose diastolic function was normal, 7.8 percent in those who had mild dysfunction, and 12.2 percent in those with moderate or severe dysfunction. After adjustment for age, hypertension, diabetes, and coronary artery disease, diastolic dysfunction was correlated with incident heart failure (hazard ratio, 1.81).

"Left ventricular diastolic dysfunction is highly prevalent, tends to worsen over time, and is associated with advancing age," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

Abdominal Pain: An Approach to a Challenging Diagnosis
AACN Advanced Critical Care, July/September 2014
Free access will expire on October 13, 2014.


HIPAA Compliance Practice Tips
Professional Case Management, July/August 2014
Free access will expire on September 29, 2014.


Follow the leader: How does “followership” influence nurse burnout?
Nursing Management, August 2014
Free access will expire on September 29, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events