Metabolic Syndrome Linked to Chronic Kidney Disease Risk

Metabolic syndrome and its components up risk for <60 ml/min/1.73 m² microalbuminuria, proteinuria

TUESDAY, Aug. 30 (HealthDay News) -- Metabolic syndrome (MetS) and its components are significantly associated with the development of estimated glomerular filtration rates (eGFR) less than 60 ml/min/1.73 m², according to a meta-analysis published online Aug. 18 in the Clinical Journal of the American Society of Nephrology.

George Thomas, M.D., from the Cleveland Clinic in Ohio, and colleagues systematically reviewed available literature to 2010 to identify the association between MetS, its components, and the development of microalbuminuria or proteinuria and CKD. A total of 11 prospective cohort confidence interval (CI) studies that included 30,146 participants were analyzed. For eGFR less than 60 ml/min/1.73 m² risk estimates were extracted from individual studies, and pooled using a random effects model. The small number of studies did not enable pooling for proteinuria outcomes.

The investigators found that MetS correlated significantly with an eGFR of less than 60 ml/min/1.73 m² (odds ratio, 1.55), with the strength of association increasing with increasing number of components of MetS. The odds ratios for developing an eGFR of less than 60 ml/min/1.73 m² for individual components of MetS were 1.61, 1.27, 1.23, 1.19, and 1.14 for elevated blood pressure, elevated triglycerides, low high density lipoprotein cholesterol, abdominal obesity, and impaired fasting glucose, respectively. Increased risk for microalbuminuria or overt proteinuria with MetS was reported in three studies.

"MetS and its components are associated with the development of eGFR <60 ml/min/1.73 m² and microalbuminuria or overt proteinuria," the authors write.

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