Early Plasma Exchange Tied to Improved Course of HUS

Beneficial for adults with hemolytic uremic syndrome caused by E. coli O104:H4

FRIDAY, Aug. 26 (HealthDay News) -- Early plasma exchange therapy is associated with increased median platelet count and glomerular filtration rate, decreased median lactate dehydrogenase concentration, and improved neurological status in adults with diarrhea-associated hemolytic uremic syndrome (HUS), according to a study published online Aug. 25 in The Lancet.

Edin Colic, M.D., from Odense University Hospital in Denmark, and colleagues investigated the benefit of plasma exchange therapy in the management of diarrhea-associated HUS induced by shiga-toxin-producing Escherichia coli serotype O104:4. Five patients (median age 62 years) diagnosed with diarrhea-associated HUS were treated with daily plasma exchange by centrifugation and substitution with fresh, frozen plasma. Stool culture and serological testing were done to identify the cause of the disease, and changes in plasma count, glomerular filtration rate, and lactate dehydrogenase were evaluated to determine the success of disease management with plasma exchange therapy.

The investigators identified increased median platelet count and glomerular filtration rate, decreased lactate dehydrogenase concentration, and improved neurological status after plasma exchange. A significant inverse correlation was observed between the time intervals from onset of bloody diarrhea to start of plasma exchange with reduction of lactate dehydrogenase concentration by plasma exchange. Seven days (range five to eight) after starting plasma exchange, all the patients were discharged with normal neurological status.

"Early plasma exchange might ameliorate the course of diarrhea-associated hemolytic uremic syndrome in adults," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events