Variable Survival Benefit of Radioembolization in HCC

Disease stage, ECOG status, hepatic function, tumor burden, extrahepatic disease affect survival

WEDNESDAY, Aug. 31 (HealthDay News) -- The survival benefit for patients with hepatocellular carcinoma (HCC) treated with radioembolization with yttrium-90-labeled resin microspheres is affected by numerous factors with the most significant, independent prognostic factors including Eastern Cooperative Oncology Group (ECOG) performance status, international normalized ratio >1.2, tumor burden and extrahepatic disease, according to a study published online June 30 in Hepatology.

Bruno Sangro, M.D., Ph.D., from the Clinica Universidad de Navarra Avda in Spain, and colleagues evaluated the prognostic factors driving survival after radioembolization with yttrium-90labeled resin microspheres in 325 HCC patients who received median activity of 1.6 GBq in whole-liver or right-lobe infusions between September 2003 and December 2009. Most patients (82.5 percent) were Child-Pugh class A, with underlying cirrhosis (78.5 percent) and good ECOG performance status (87.7 percent). Many had multinodular disease (75.9 percent) invading both lobes and/or the portal vein. More than 50 and 25 percent had advanced and intermediate Barcelona Clinic Liver Cancer (BCLC) staging, respectively.

The investigators found that the median overall survival of 12.8 months varied significantly by disease stage, ECOG status, hepatic function, tumor burden, and extrahepatic disease. With references to BCLC staging, tumor burden and liver function were additional factors in determining prognosis. Multivariate analysis confirmed ECOG status, tumor burden, international normalized ratio >1.2, and extrahepatic disease as the most significant independent prognostic factors. Common adverse events were fatigue, nausea/vomiting, and abdominal pain. All-cause mortality at 30 and 90 days was 0.6 percent and 6.8 percent, respectively.

"This analysis provides robust evidence of the survival achieved with radioembolization, including those with advanced disease and few treatment options," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events