View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
THURSDAY, Sept. 1 (HealthDay News) -- NPe6-photodynamic therapy (PDT) is a better treatment for patients with lung cancer than photofrin-PDT, and the efficacy of PDT may improve based on individual expression status of the anti-apoptotic protein Bcl-2 and breast cancer-resistant protein (BCRP), according to a study published online Aug. 23 in Lasers in Surgery and Medicine.
Jitsuo Usuda, M.D., from the Tokyo Medical University, and colleagues analyzed the molecular mechanism of PDT using photofrin and NPe6, and compared the two treatments. The role of immunological reactions in the anti-tumor effects of PDT, using cytokine-over-expressing cells was assessed. In addition they evaluated whether Bcl-2 is a molecular target. The association between adenosine triphosphate-binding cassette transporter proteins such as BCRP and the efficacy of PDT was also evaluated using clinical samples from 81 early lung cancer lesions treated with PDT between 1998 and 2006.
The investigators found damaged Bcl-2 and rapidly induced apoptosis with photofrin-PDT but not NPe6-PDT. A strong anti-tumor effect was exerted by NPe6-PDT irrespective of Bcl-2 over-expression. Photofrin, and not NPe6, was found to be a substrate of BCRP, with all 81 lung cancer lesions found to be BCRP-positive. The expression of BCRP significantly affected the efficacy of photofrin-PDT. NPe6-PDT exerted a strong anti-tumor effect with much higher complete response rate after NPe6-PDT than after photofrin-PDT, irrespective of BCRP expression.
"NPe6-PDT may be superior to photofrin-PDT for the treatment of lung cancer, and individualized approaches to PDT based on the expression status of Bcl-2 and/or BCRP may improve the efficacy of PDT in patients with lung cancers," the authors write.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top