Gestational NSAID Intake Tied to Spontaneous Abortion Risk

Risk increases with any type, dosage of nonaspirin NSAIDs separately or in combination

WEDNESDAY, Sept. 7 (HealthDay News) -- Exposure to any type or dosage of nonaspirin nonsteroidal anti-inflammatory drug (NSAID) in early pregnancy increases the risk of spontaneous abortion, according to a study published online Sept. 6 in CMAJ, the journal of the Canadian Medical Association.

Hamid Reza Nakhai-Pour, M.D., Ph.D., from the University of Montreal, and colleagues quantified the association between spontaneous abortion and types and dosages of nonaspirin NSAIDs in a study of 4,705 pregnant women from the Quebec Pregnancy Registry who had a spontaneous abortion. Ten controls were selected for each case from the remaining women in the group, and they were matched by date of the spontaneous abortion and gestational age. Use versus nonuse of NSAIDS was evaluated, along with associations between the spontaneous abortion and type and dosage of NSAIDs. Conditional logistic regression was utilized for analyses of associations and adjustment for confounding factors.

The investigators found that the use of nonaspirin NSAIDs during pregnancy was associated with a significant risk of spontaneous abortion after adjusting for potential confounders (odds ratio [OR], 2.43). The use of diclofenac, naproxen, celecoxib, ibuprofen, and rofecoxib alone, or combinations thereof, was correlated with an increased risk of spontaneous abortion (OR of 3.09, 2.64, 2.21, 2.19, 1.83, and 2.64, respectively). There was no evident dose-response effect.

"Gestational exposure to any type or dosage of nonaspirin NSAIDs may increase the risk of spontaneous abortion," the authors write.

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