Tissue Factor Pathway Inhibitor Levels Up in Women With MI

Increased tissue factor pathway inhibitor activity, activated protein C-sensitivity linked to MI

THURSDAY, Sept. 15 (HealthDay News) -- Young women with myocardial infarction (MI) have higher tissue factor pathway inhibitor (TFPI) levels in comparison to those without MI, with increased TFPI activities and activated protein C (APC)-sensitivity correlating with MI, according to a study published online Sept. 5 in the Journal of Thrombosis and Haemostasis.

Kristien Winckers, M.D., from the Maastricht University Medical Center in the Netherlands, and colleagues investigated the influence of the TFPI/protein S anticoagulant system on the risk of MI in women younger than 50 years. A total of 205 women with MI and 638 controls were enrolled, and underwent enzyme-linked immunosorbent assay to quantify TFPI and protein S. Thrombin generation tests were used to determine TFPI/protein S activity and APC-sensitivity ratio.

The investigators found that women with MI had elevated levels of TFPI (135.9 ± 40 percent versus 124.2 ± 41 percent) resulting in increased TFPI/protein S activities and increased APC-sensitivity. Increased TFPI activity was correlated with MI (adjusted odds ratio [OR] quartile one versus quartile four, 2.1). APC-sensitivity was also correlated with MI (adjusted OR quartile one versus quartile four, 1.7; 95 percent confidence interval, 0.9 to 3.2).

"Women with MI have increased TFPI levels compared with controls. Consequently, the TFPI/protein S activity and APC-sensitivity are increased in women with MI," the authors write.

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events