Long-Term Nonaspirin NSAID Use Ups Renal Cell Cancer Risk

Nonsteroidal anti-inflammatory drugs, but not aspirin or acetaminophen, increase RCC risk

WEDNESDAY, Sept. 14 (HealthDay News) -- Use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs), but not aspirin and acetaminophen, is associated with an increased risk of renal cell cancer (RCC), with increased duration of use correlated with an elevated risk, according to a study published in the Sept. 12 issue of the Archives of Internal Medicine.

Eunyoung Cho, Sc.D., from Harvard Medical School in Boston, and colleagues investigated the correlation between analgesic use and RCC in 77,525 women followed up for 16 years, and 49,403 men followed up for 20 years. Data collected from the Health Professionals Follow-up Study in 1986 and from the Nurses' Health Study in 1990, and every two years thereafter were used to assess baseline and duration of analgesic use. A total of 333 RCC cases were identified.

The investigators found that aspirin and acetaminophen use did not correlate with RCC risk, but regular use of nonaspirin NSAIDs correlated with increased RCC risk (pooled multivariate relative risk, 1.51 at baseline). The absolute risk differences for users compared to nonusers of nonaspirin NSAIDs were 9.15 and 10.92 per 100,000 person-years for women and men, respectively. Compared to non-regular use of nonaspirin NSAIDs, the pooled multivariate relative risks for regular use were 0.81 (95 percent confidence interval [CI], 0.59 to 1.11) for less than four years of use; 1.36 (95 percent CI, 0.98 to 1.89) for four to less than 10 years of use; and 2.92 (95 percent CI, 1.71 to 5.01) for 10 or more years of use, which showed significance for the trend.

"Longer duration of use of nonaspirin NSAIDs may increase the risk of RCC," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events