Thrombomodulin Gene Variants Up Post-CABG Mortality Risk

Homozygote minor allele of rs3176123 independently predicts all-cause mortality

FRIDAY, Sept. 16 (HealthDay News) -- Genetic variants in the thrombomodulin gene (THBD) are independently associated with an increased risk of long-term all-cause mortality after coronary artery bypass graft (CABG) surgery, according to a study published in the Sept. 13 issue of Circulation.

Robert L. Lobato, M.D., from the Stanford University School of Medicine in California, and colleagues investigated the association of genetic variants in thrombotic and inflammatory pathways with long-term mortality in patients from two study cohorts who underwent CABG surgery. The National Death Index was used to identify all-cause mortality between 30 days and five years after surgery. Clinical and genomic multivariate predictors of incident death were identified by testing a panel of 90 single-nucleotide polymorphisms (SNPs) in 49 candidate genes in a discovery cohort of 1,018 patients. In a validation cohort of 930 patients, six tag SNPs in the thrombomodulin THBD gene were assessed, one of which (rs3176123) was in complete linkage disequilibrium with rs1042579.

The investigators found that the homozygote minor allele of a common variant in the THBD gene (rs1042579) was independently correlated with a significantly elevated risk of all-cause mortality (hazard ratio [HR], 2.26), after adjusting for multiple comparisons and clinical predictors of mortality. The homozygote minor allele of rs3176123 significantly and independently predicted all-cause mortality (HR, 3.6), after adjustment for the clinical predictors identified in the discovery cohort and multiple testing.

"In two independent cardiac surgery cohorts, linked common allelic variants in the THBD gene are independently associated with increased long-term mortality risk after CABG," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events