Stroke Outcomes Similar With CT-Perfusion, Time Criteria

Outcomes comparable when using CT-perfusion criteria for endovascular stroke treatment

THURSDAY, Sept. 22 (HealthDay News) -- For patients with ischemic stroke, use of computed tomography perfusion (CTP)-based criteria for selecting patients for endovascular treatment has similar rates of functional outcome and intracranial hemorrhage compared to time-guided selection, according to a study published online Sept. 19 in the Journal of Neurointerventional Surgery.

Aquilla Turk, M.D., from the Medical University of South Carolina in Charleston, and colleagues investigated the use of CTP-based criteria in the selection of patients for intra-arterial treatment of ischemic stroke. CTP maps of 53 patients with a National Institute of Health Stroke Scale score of 8 or more were evaluated retrospectively for the presence of penumbra and infarction. The functional outcome was recorded using the modified Rankin scale (mRS) at or closest to 90 days follow-up.

The investigators found that the median time from symptom onset to groin vascular access was 6.3 hours. A total of eight patients had bleeding complications, including subarachnoid, parenchymal, and intraventricular hemorrhage. The patients were divided according to time from symptom onset until endovascular procedure (six hours or less versus more than six hours). No significant difference was found between the groups in terms of functional outcome (38.5 and 40.7 percent, respectively, had 90 day mRS of ≤2; 57.7 and 51.9 percent, respectively, had 90 day mRS ≤3) or rate of intracranial hemorrhage (11.5 and 18.5 percent, respectively).

"This study demonstrated similar rates of good functional outcome and intracranial hemorrhage in patients with ischemic stroke when endovascular treatment was performed based on CTP selection rather than time-guided selection," the authors write.

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