Total Sleep Time Tied to Obese Teen Glucose Homeostasis

Decreased slow-wave sleep duration is linked to decreased insulin secretion

FRIDAY, Sept. 23 (HealthDay News) -- Inadequate or excessive sleep is associated with disruptions in insulin secretion and glucose homeostasis in obese adolescents, according to a study published online Sept. 20 in Diabetes Care.

Dorit Koren, M.D., from the Children's Hospital of Philadelphia, and colleagues investigated the association of altered sleep architecture and sleep deprivation with glucose homeostasis as well as insulin secretion and sensitivity in 62 obese adolescents. Assessments included oral glucose tolerance test (OGTT), anthropometric measurements, overnight polysomnography, and frequently sampled intravenous glucose tolerance test. Sleep architecture was evaluated, hemoglobin A1c (HbA1c) and serial glucose and insulin levels were obtained, and calculations were made of indices of insulin sensitivity and secretion. Adjustments were made for confounding variables, and regression and correlation analyses evaluated the associations of total sleep and sleep stages with measures of insulin and glucose homeostasis.

The investigators found that sleep duration had significant U-shaped (quadratic) associations with both HbA1c and serial glucose levels on OGTT. Slow-wave sleep duration was positively associated with insulin secretory measures, even after adjusting for degree of obesity, stage of puberty, gender, and obstructive sleep apnea measures.

"Ensuring adequate sleep might reduce the risk of type 2 diabetes mellitus in at-risk obese adolescents," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events