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FRIDAY, Sept. 23 (HealthDay News) -- Inadequate or excessive sleep is associated with disruptions in insulin secretion and glucose homeostasis in obese adolescents, according to a study published online Sept. 20 in Diabetes Care.
Dorit Koren, M.D., from the Children's Hospital of Philadelphia, and colleagues investigated the association of altered sleep architecture and sleep deprivation with glucose homeostasis as well as insulin secretion and sensitivity in 62 obese adolescents. Assessments included oral glucose tolerance test (OGTT), anthropometric measurements, overnight polysomnography, and frequently sampled intravenous glucose tolerance test. Sleep architecture was evaluated, hemoglobin A1c (HbA1c) and serial glucose and insulin levels were obtained, and calculations were made of indices of insulin sensitivity and secretion. Adjustments were made for confounding variables, and regression and correlation analyses evaluated the associations of total sleep and sleep stages with measures of insulin and glucose homeostasis.
The investigators found that sleep duration had significant U-shaped (quadratic) associations with both HbA1c and serial glucose levels on OGTT. Slow-wave sleep duration was positively associated with insulin secretory measures, even after adjusting for degree of obesity, stage of puberty, gender, and obstructive sleep apnea measures.
"Ensuring adequate sleep might reduce the risk of type 2 diabetes mellitus in at-risk obese adolescents," the authors write.
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