Hospitalization, Complication Risk Up After Prostate Biopsy

Nearly double the 30-day hospitalization risk versus controls, infectious complications also up

FRIDAY, Sept. 23 (HealthDay News) -- Men who undergo prostate biopsy have nearly double the risk of hospitalization within 30 days versus those who do not, and the rate of infectious complications after prostate biopsy has increased in recent years, according to a study published online Sept. 23 in The Journal of Urology.

Stacy Loeb, M.D., from the Johns Hopkins Medical Institutions in Baltimore, and colleagues investigated the risk of serious complications requiring hospitalizations following prostate biopsy and predictors of serious infectious and noninfectious complications over time. The rates of 30-day hospitalizations and International Classification of Diseases, ninth edition primary diagnosis codes for admissions were compared for 17,472 Medicare recipients who underwent prostate biopsy and 134,977 controls.

The investigators found that the 30-day hospitalization rate after biopsy was 6.9 percent in men who underwent prostate biopsy and 2.9 percent in controls. After multivariate adjustments, prostate biopsy was correlated with a 2.65-fold greater risk of hospitalization within 30 days versus controls. A significantly greater risk of infectious complications requiring hospitalization after biopsy was seen in recent years. For men undergoing biopsy, year, nonwhite race and higher comorbidity scores were significantly correlated with an increased risk of infectious complications.

"After demographic adjustments, prostate biopsy was associated with a significantly increased risk of hospitalization, and serious infectious and noninfectious complications," the authors write. "Taken together, these findings highlight the importance of careful patient selection and counseling regarding prostate biopsy."

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