Rapeseed Oil Rapidly Improves Hyperlipidemia

Replacing saturated dairy fat-rich diet with rapeseed oil lowers lipoprotein, triglyceride level

THURSDAY, Sept. 29 (HealthDay News) -- For hyperlipidemic individuals, replacing a diet rich in saturated dairy fat (DF) with a rapeseed oil (RO)-based diet for three weeks improves the serum lipoprotein profile, with reductions in triglyceride levels, according to a study published in the October issue of the Journal of Internal Medicine.

David Iggman, from Uppsala University in Sweden, and colleagues investigated the impact of replacing a diet rich in saturated DF with a diet including RO-based fat on lipoprotein profile, coagulation factors, and insulin sensitivity in 20 hyperlipidemic individuals. In a crossover study, isocaloric test diets, either DF- or RO-based, were given over two three-week periods. Insulin sensitivity, blood lipoprotein profile, coagulation, and fibrinolytic factors were analyzed before and after the dietary intervention.

The investigators found changes in serum fatty acids indicative of high compliance. The RO but not DF diet correlated with reduction in levels of the following from baseline: serum cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, cholesterol/high-density lipoprotein (HDL) cholesterol ratio, apolipoprotein (apo) B/apo A-I ratio, and factor VII coagulant activity (FVIIc). These reductions were significantly different between the diets, with the exception of the reductions in FVIIc. The RO but not the DF diet showed a modest increase in serum lipoprotein, and a trend toward increased glucose disappearance rate. The HDL cholesterol, insulin sensitivity, fibrinogen, and tissue plasminogen activator inhibitor-1 levels did not differ between diets nor change from baseline.

"Replacing DF with RO causes marked improvement of serum lipoprotein profile, including lowering of LDL cholesterol and triglycerides after only three weeks," the authors write.

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