Colorectal Cancer Subsite Risk Tied to Fruit/Vegetable Intake

Fruit/vegetable intake affects proximal colon, distal colon, rectal cancer risk differently

TUESDAY, Sept. 27 (HealthDay News) -- The risk of colorectal cancer (CRC) associated with different fruit and vegetable (F/V) consumption varies depending on the tumor location within the large bowel, according to a study published online Sept. 26 in the Journal of the American Dietetic Association.

Neeltje Annema, from the Western Australian Institute for Medical Research in Nedlands, and colleagues investigated whether the relationship between F/V intake and CRC risk varied by subsite of the bowel (proximal colon, distal colon, and rectum). Data for 834 CRC cases and 939 controls were collected from food frequency questionnaires completed between 2005 and 2007. Logistic regression analysis estimated the effects of F/V intake quartiles (Q1 to Q4) on CRC risk stratified by bowel subsite. Odds ratios (ORs) for overall and individual subsite CRC risk were calculated.

The investigators found that the risk of rectal and proximal colon cancer did not correlate with total F/V, total fruit, or total vegetable consumption. There was an inverse relationship between consumption of brassica vegetables and proximal colon cancer risk (Q4 versus Q1 OR, 0.62). Distal colon cancer showed significant negative tendencies for total F/V and total vegetable intake. The risk of distal colon cancer was lowered significantly with increased intake of dark yellow vegetables and apples (Q4 versus Q1 OR, 0.61 and 0.51, respectively). An increased risk of CRC correlated with intake of fruit juice (Q4 versus Q1 OR, 1.74).

"Our results suggest that different F/V may confer different risks for cancer of the proximal colon, distal colon, or rectum," the authors write.

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