Advanced Adenomas, CRCs More Prevalent in Men

Number needed to screen for adenomas similar in men aged 45 to 49, women aged 55 to 59

TUESDAY, Sept. 27 (HealthDay News) -- For individuals older than 50 years, men have a significantly increased prevalence of adenomas, advanced adenomas (AAs), and carcinomas compared to women, according to a study published in the Sept. 28 issue of the Journal of the American Medical Association.

Monika Ferlitsch, M.D., from the Austrian Society for Gastroenterology and Hepatology, and colleagues investigated and compared the prevalence and number needed to screen (NNS) for adenomas, AAs, and colorectal carcinomas (CRCs) for different age groups. A total of 44,350 participants, including 51 percent women and 49 percent men, with a median age of 60.7 and 60.6 years, respectively, underwent screening colonoscopy from 2007 to 2010.

The investigators found that the overall prevalence of adenomas, AAs, and CRCs was 19.7, 6.3, and 1.1 percent, respectively, and the NNS were 5.1, 15.9, and 90.9, respectively. Prevalence was significantly higher for males compared to females for adenomas (24.9 versus 14.8 percent), AAs (8.0 versus 4.7 percent), and CRCs (1.5 versus 0.7 percent), with unadjusted odds ratios of 1.9, 1.8, and 2.1, respectively. Among individuals between the ages of 50 and 54 years, AA prevalence was 5 percent in men versus 2.9 percent in women, and the NNS was 20 and 34, respectively. No statistical significance was found between the prevalence and NNS of AAs in men aged 45 to 49 years compared with women aged 55 to 59 years (3.8 versus 3.9 percent and 26.1 versus 26 percent, respectively; P = .99).

"Male sex constitutes an independent risk factor for colorectal carcinoma," the authors write.

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