Hormonal Contraceptives May Up HIV-1 Acquisition by Women

Also tied to increased risk of HIV-1 transmission from HIV-1 infected women to men

TUESDAY, Oct. 4 (HealthDay News) -- Use of hormonal contraceptives is associated with an increased risk of HIV-1 acquisition by women, and an increased risk of HIV-1 transmission from HIV-infected women to HIV-1 seronegative men, according to a study published online Oct. 4 in The Lancet Infectious Diseases.

Renee Heffron, M.P.H., from the University of Washington in Seattle, and colleagues investigated the correlation between hormonal contraceptive use and risk of acquiring HIV-1 by women, and the risk of transmission from HIV-1-infected women to their male partners. A total of 3,970 heterosexual HIV-1-serodiscordant couples from seven African countries were included in the analysis. HIV-1 seroconversion was the primary outcome during a median follow-up of 18 years.

The investigators found that, among 1,314 couples with a female HIV-1-seronegative partner, the HIV-1 acquisition rates were significantly higher for those women who used hormonal contraception compared with those who did not (6.61 and 3.78 per 100 person-years, respectively; adjusted hazard ratio [HR], 1.98). Among 2,476 couples with a male HIV-1-seronegative partner, rates of HIV-1 transmission from women to men were 2.61 and 1.51 per 100 person-years in couples with women using and women not using hormonal contraception, respectively (adjusted HR, 1.97).

"Women should be counseled about potentially increased risk of HIV-1 acquisition and transmission with hormonal contraception, especially injectable methods, and about the importance of dual protection with condoms to decrease HIV-1 risk," the authors write.

Two authors disclosed financial ties to the pharmaceutical and biomedical industries.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events