ERα Autoantibodies Affect Disease Activity in Lupus

Anti-estrogen receptor α induces cell activation by interfering with T lymphocyte homeostasis

TUESDAY, Oct. 11 (HealthDay News) -- In patients with systemic lupus erythematosus (SLE), autoantibodies specific to estrogen receptor α (anti-ERα Abs) interfere with T lymphocyte homeostasis and are significantly associated with disease activity, according to a study published online Oct. 3 in Arthritis & Rheumatism.

Tania Colasanti, Ph.D., from Istituto Superiore di Sanitá in Rome, and colleagues assessed the presence of anti-ERα and ERβ Abs in the sera from 86 patients with SLE and 95 healthy donors. Additionally, they analyzed the impact of these antibodies on peripheral blood T lymphocyte homeostasis, and their role as determinants of pathogenesis and progression. Using enzyme-linked immunosorbent assay, anti-ER Abs serum immunoreactivity was analyzed. Flow cytometry and Western blot were used for phenotypic and functional analyses.

The investigators found that anti-ERβ Abs were undetectable, but anti-ERα Abs were noted in 45 percent of patients with SLE. Anti-ERα Abs from healthy participants induced cell activation resulting in apoptotic cell death in resting lymphocytes, and anti-CD3-stimulated T lymphocyte proliferation. Anti-ERα Ab values had a significant association with clinical parameters (SLE Disease Activity Index and arthritis).

"Anti-ERα autoantibodies interfere with T lymphocyte homeostasis and are significantly associated with lupus disease activity," the authors write.

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events