Placental Protein 13 Clusters Facilitate Trophoblast Invasion

PP13-mediated decidual necrosis zones may divert maternal immune system from spiral arterioles

TUESDAY, Oct. 11 (HealthDay News) -- Placental protein 13 (PP13 or galectin 13) forms perivenous aggregates that attract and activate maternal immune cells to create decidual zones of necrosis (ZONEs), which facilitate trophoblast invasion and conversion of the maternal spiral arterioles in preeclampsia, according to a study published online Oct. 11 in Reproductive Sciences.

Harvey J. Kliman, M.D., Ph.D., from Yale University in New Haven, Conn., and colleagues assessed the role of PP13 in trophoblast invasion and decidual necrosis in early preeclampsia. Immunohistochemical analysis was carried out on 20 elective pregnancy termination specimens between 6 and 15 weeks of gestation to assess PP13, immune cells, human placental lactogen, cytokeratin, and markers of apoptosis.

The investigators found that PP13 was localized to the occasional multinucleated luminal trophoblasts within converted decidual spiral arterioles, and to syncytiotrophoblasts in the chorionic villi. PP13 staining was not seen in cytotrophoblasts, anchoring trophoblasts, or invasive trophoblasts. Extracellular PP13 aggregates were localized around ZONEs which comprised decidual veins associated with T-cells, neutrophils, and macrophages.

"Our studies suggest that PP13-mediated ZONEs within normal human gestational decidua may be a novel mechanism to divert maternal immune surveillance away from the spiral arterioles," the authors write.

Several of the study authors disclosed financial ties with Diagnostic Technologies Ltd.

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95

Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95

Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events