Urinary Marker ID'd for Long-Term Mortality in Diabetes

Urinary excretion of RNA oxidation marker predicts long-term mortality in type 2 diabetes

TUESDAY, Oct. 18 (HealthDay News) -- For patients with type 2 diabetes, urinary excretion of the marker of the RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) predicts long term all-cause and diabetes-related mortality, but excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) do not, according to a study published online Oct. 12 in Diabetes Care.

Kasper Broedbaek, M.D., from the Rigshospitalet in Copenhagen, Denmark, and colleagues investigated whether urinary markers of nucleic acid oxidation acted as independent predictors of long-term mortality in 1,381 patients (aged 40 years or more) with newly diagnosed type 2 diabetes. Participants provided freshly voided morning urine samples soon after their diagnosis of type 2 diabetes, which were then stored at −80 degrees Celsius. The 8-oxodG and 8-oxoGuo were measured in these samples by ultra performance liquid chromatography and tandem mass spectrometry.

The investigators found that the multivariate adjusted hazard ratio was 1.44 for all-cause mortality and 1.54 for diabetes-related mortality in patients with 8-oxoGuo levels in the highest tertile compared to those in lowest tertile. In adjusted analysis, there was no significant correlation between 8-oxodG and mortality.

"Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors," the authors write.

The study was partially supported by Novo Nordisk Farmaka Denmark Ltd.

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