Excision Margin of 2 cm Safe in Melanoma Thicker Than 2 mm

Overall five-year survival in cutaneous melanoma similar with 2-cm, 4-cm resection margins

MONDAY, Oct. 24 (HealthDay News) -- For patients with cutaneous melanoma thicker than 2 mm, a surgical excision margin of 2 cm is sufficient and has similar overall survival as with a 4-cm excision margin, according to a study published online Oct. 24 in The Lancet.

Peter Gillgren, M.D., from the Karolinska Institutet in Stockholm, Sweden, and colleagues compared survival with surgical resection margin of 2 cm versus 4 cm in a controlled trial of 936 patients with clinical stage IIA to C cutaneous melanoma thicker than 2 mm. Randomization was done by sealed envelope or by computer generated lists with permuted blocks, and 465 and 471 participants were allocated to treatment with a 2-cm or a 4-cm resection margin, respectively. One patient died in each group during follow-up but were included in the analysis. Overall survival was the primary end point. No systematic recording was done for adverse events.

The investigators found that, after a median follow-up of 6.7 years, 181 and 177 patients died in the 2-cm and 4-cm margin groups, respectively (hazard ratio, 1.05; 95 percent confidence interval, 0.85 to 1.29). The five-year overall survival was the same in both groups at 65 percent.

"Our findings suggest that a 2-cm resection margin is sufficient and safe for patients with cutaneous melanoma thicker than 2 mm," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95

Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95

Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events