HPV Infection, Cardiovascular Disease in Women Linked

Particularly cancer-associated HPV type linked to higher cardiovascular disease risk among women

MONDAY, Oct. 24 (HealthDay News) -- Human papillomavirus (HPV) infection in women, especially tumor-associated oncogenic HPV, is correlated with an increased risk of cardiovascular disease (CVD), according to a study published in the Nov. 1 issue of the Journal of the American College of Cardiology.

Hsu-Ko Kuo, M.D., M.P.H., and Kenichi Fujise, M.D., from the University of Texas Medical Branch at Galveston, investigated whether HPV infection was associated with CVD risk in 2,450 women (aged 20 to 59 years) who participated in the National Health and Nutrition Examination Survey between 2003 and 2006. The presence of HPV DNA in self-collected vaginal swab specimens was detected by L1 consensus polymerase chain reaction followed by type-specific hybridization. Self-reported diagnosis of myocardial infarction or stroke was used as an indication of CVD.

The investigators found that 60 women had CVD, of which 39 were positive for HPV DNA, and 21 were negative. After adjusting for demographics, health/gender behaviors, medical comorbidities, cardiovascular risk factors, and management, women with the presence of vaginal HPV DNA were more likely to have CVD than those without (odds ratio [OR], 2.30). After similar adjustments, women with cancer-associated HPV types had increased odds of CVD than those who were negative for HPV (OR, 2.86).

"HPV infection, especially cancer-associated oncogenic types, is associated with CVD among women," the authors write.

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