Ovarian Stimulation Ups Risk of Ovarian Tumors in Later Life

Increased risk of ovarian stimulation for IVF seen in particular with borderline ovarian tumors

THURSDAY, Oct. 27 (HealthDay News) -- Ovarian stimulation for in vitro fertilization (IVF) is associated with an increase in the risk of ovarian malignancies, especially borderline ovarian tumors, according to a study published online Oct. 26 in Human Reproduction.

Flora E. van Leeuwen, Ph.D., from the Netherlands Cancer Institute in Amsterdam, and colleagues assessed the long-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies in 19,146 women who received IVF treatment in the Netherlands between 1983 and 1995, and 6,006 subfertile women who did not undergo IVF. Data were collected from 65 percent of the women between 1997 and 1999 on reproductive risk factors, and data on subfertility (treatment) were collected from medical records. The incidence of ovarian malignancies was assessed though 2007 via linkage to disease registries. Participants were followed up for 14.7 years and the risk of ovarian malignancies in the IVF group, the general population, and the subfertile comparison group were compared.

The investigators found a significantly increased risk of borderline ovarian tumors in the IVF group compared with the general population (standardized incidence ratio [SIR], 1.76). There was no significant increase in the overall SIR for invasive ovarian cancer, but incidence increased with longer follow-up after the first IVF (SIR after 15 years, 3.54). Compared with the subfertile group, the risks of borderline ovarian tumors and all ovarian malignancies combined were significantly elevated in the IVF group (hazard ratios, 4.23 and 2.14, respectively).

"Knowledge about the magnitude of the risks associated with ovarian stimulation is important for women considering starting or continuing IVF treatment, as well as their treating physicians," the authors write.

One of the study authors disclosed financial ties to MSD and Ferring.

Abstract
Full Text

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events