Paternal Fetal IGF2 Variants Up Maternal Glucose Levels

Four paternally transmitted variants tied to higher maternal glucose in third trimester

FRIDAY, Oct. 28 (HealthDay News) -- Paternally transmitted fetal IGF2 variants are associated with increased maternal glucose concentrations in the third trimester of pregnancy, according to a study published in the November issue of Diabetes.

Clive J. Petry, Ph.D., from the University of Cambridge in the United Kingdom, and colleagues investigated the association between polymorphic variation in the paternally transmitted fetal IGF2 gene and maternal circulating glucose concentrations in the third trimester of pregnancy. A total of 17 haplotype tag single nucleotide polymorphisms in the IGF2 region were selected from 1,160 mother/partner/offspring trios from two studies. Associations between inferred parent-of-origin fetal alleles, maternal glucose z score at 60 minutes following an oral glucose load at week 28 of pregnancy, and offspring birth weights were established.

The investigators found that paternally transmitted fetal IGF2 polymorphisms, specifically rs6578987, rs680, rs10770125, and rs7924316 alleles, were significantly associated with elevated maternal glucose concentrations in the third trimester, and with placental IGF-II contents at birth. However, maternal glucose concentrations were not associated with maternal or maternally-transmitted fetal IGF2 genotypes.

"The significant associations between paternally transmitted fetal alleles and maternal glucose z scores are unique findings, in terms of both IGF2 and finding associations between genetic variation in paternally transmitted genes and maternal glucose tolerance in pregnancy," the authors write.

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