Graft Loss Higher With Kidneys Donated by Older Live Donors

But comparable to graft loss for recipients of a kidney from a deceased younger donor

THURSDAY, Nov. 3 (HealthDay News) -- For kidney recipients, graft loss is significantly higher when the live donor is age 70 years or older than when the live donor is aged 50 to 59 years, but is comparable to that from a deceased donor aged 50 to 59 years, according to a study published online Oct. 27 in the Clinical Journal of the American Society of Nephrology.

Jonathan C. Berger, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues compared outcomes for recipients of a kidney from older donors and younger donors. Data were collected from 219 live donors aged 70 to 84, and were compared with data from matched recipients from living and deceased donors aged 50 to 59 years. The independent correlation between older donor age and allograft survival was assessed by using competing risks models, accounting for the recipient mortality risk and other factors. Donor survival was compared with matched controls from the National Health and Nutrition Examination Survey III (NHANES-III).

The investigators found that graft loss was significantly higher among recipients of older live donor allografts versus matched younger live donor allografts (subhazard ratio [SHR], 1.62), but was similar to matched nonextended criteria younger deceased donor allografts (SHR, 1.19; 95 percent confidence interval, 0.87 to 1.63). Mortality among living kidney donors aged 70 years or more was lower than that of healthy matched controls from NHANES-III (hazard ratio, 0.37).

"Recipients of live donor kidneys aged ≥70 had a significantly higher rate of graft loss compared with recipients of younger live donor kidneys aged 50 to 59," the authors write.

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