Exercise Lowers CVD Death Risk Irrespective of Metabolic Factors

Physical activity protective for CVD mortality in healthy adults, those with metabolic risks

MONDAY, Nov. 7 (HealthDay News) -- Physical activity is associated with lower risk for cardiovascular disease (CVD) mortality, independent of metabolic risk factors, according to a study published in the Nov. 15 issue of The American Journal of Cardiology.

Jacinta I. Reddigan, from York University in Toronto, and colleagues investigated the influence of metabolic risk factors on the association between CVD mortality and physical activity, and examined the protective effect of physical activity on CVD mortality risk in healthy adults and those with metabolic risk factors. Data were collected for 10,261 adults with a follow-up period of 13.4 ± 3.9 years. Participants completed questionnaires on physical activity, which was classified into inactive, light, and moderate/vigorous. Clinical thresholds were used to classify metabolic risk factors, including dyslipidemia, type 2 diabetes mellitus, obesity, hypertension, inflammation, and insulin resistance.

The investigators found that light or moderate/vigorous physical activity was associated with significantly lower CVD mortality risk after adjustment for basic confounders, and this association was only slightly attenuated following adjustment for each risk-factor set. Participants who engaged in light and moderate/vigorous physical activity remained at lower risk of CVD mortality (hazard ratio, 0.72 and 0.72, respectively), after simultaneous addition of all risk-factor sets to the model. Physical activity offered protection for CVD mortality risk in healthy individuals and those with isolated or clustered metabolic risk factors.

"Physical activity was associated with a lower risk of CVD mortality independent of traditional and inflammatory risk factors," the authors write.

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