Higher Coffee Consumption May Lower Endometrial Cancer Risk

Drinking four or more cups per day associated with a 25 percent reduced endometrial cancer risk

TUESDAY, Nov. 22 (HealthDay News) -- Consumption of four or more cups of coffee per day is associated with a 25 percent reduced risk of endometrial cancer, according to a study published online Nov. 22 in Cancer Epidemiology, Biomarkers & Prevention.

Youjin Je, from the Harvard School of Public Health in Boston, and colleagues investigated the correlation between coffee consumption and the risk of endometrial cancer. Data from the Nurses' Health Study for 67,470 women aged 34 to 59 in 1980 were assessed. The long-term effects of coffee were evaluated from the cumulative average coffee intake based on data from all available questionnaires.

The investigators found that drinking less than four cups of coffee per day was not associated with the risk of endometrial cancer. Compared with women who consumed less than one cup of coffee per day, those women who consumed four or more cups of coffee per day had a 25 percent reduced risk of endometrial cancer (multivariable rate ratio [RR], 0.75). A similar association was observed with caffeinated coffee consumption (RR for at least four versus less than one cups/day, 0.70). An inverse association was found among women who consumed two or more cups of decaffeinated coffee per day versus those who consumed less than one cup per month. No association was found between tea consumption and the risk of endometrial cancer.

"Our findings provide prospective evidence with the potential beneficial role of four or more cups of coffee per day against endometrial cancer risk," the authors write.

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