Cold Sore Susceptibility Linked to SNPs on C21orf91

Association seen in linkage analysis, parental transmission disequilibrium testing

FRIDAY, Dec. 2 (HealthDay News) -- Single nucleotide polymorphisms (SNPs) on C21orf91 are associated with herpes simplex labialis (HSL) susceptibility, according to a study published in the Dec. 1 issue of the Journal of Infectious Diseases.

John D. Kriesel, M.D., from the University of Utah School of Medicine in Salt Lake City, and colleagues evaluated the association of individual SNPs on six candidate genes within a 3-megabase region on human chromosome 21, with HSL frequency. A total of 355 individuals, who were seropositive for herpes simplex virus type 1, were examined for annual HSL frequency. Their individual genotypes were determined by SNPlex for linkage analysis and parental transmission disequilibrium testing (ParenTDT).

The investigators found that, based on two-point linkage analysis, cold sore frequency was positively linked with two SNPs within the C21orf91 region, of which one was nonsynonymous. ParenTDT analysis identified a significant, robust correlation between frequent HSL and another C21orf91 SNP, predicted to lie in the 3' untranslated region.

"Two complementary techniques identified C21orf91 as a gene of interest for susceptibility to HSL. We propose that C21orf91 be designated the Cold Sore Susceptibility Gene-1," the authors write.

The HSV-1 type-specific serology kits were donated by Focus Technologies.

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