SABCS: Adjuvant Bevacizumab Ups Progression-Free Survival

Statistically significant improvement seen in Independent Review Committee assessment

THURSDAY, Dec. 8 (HealthDay News) -- For patients with human epidermal growth factor receptor 2 (HER2)-positive, locally recurrent/metastatic breast cancer (LR/mBC), the addition of bevacizumab (BEV) to trastazumab (H) and docetaxel (DOC) is associated with an increase in progression-free survival (PFS), according to a study presented at the annual San Antonio Breast Cancer Symposium, held from Dec. 6 to 10.

Luca Gianni, M.D., Ph.D., from Ospedale San Raffaele in Milan, Italy, and colleagues investigated the efficacy of H + DOC compared with H + DOC + BEV, in the first randomized trial in HER2-positive LR/mBC. A total of 424 eligible patients, enrolled from 60 centers between September 2006 and February 2010, were randomly allocated to receive H + DOC (208 participants) or H + DOC + BEV (216 participants). The primary end point measured was PFS. Patients from both treatment groups were followed for a median of 26 months.

The investigators found that there were 154 events in the H + DOC group and 153 in the H + DOC + BEV group (74 and 71 percent, respectively; hazard ratio [HR] on unstratified analysis, 0.82; 95 percent confidence interval, 0.65 to 1.02). The median PFS was significantly increased in the group with adjuvant BEV (16.5 versus 13.7 months; HR in stratified analysis, 0.76). In an Independent Review Committee assessment, stratified and censored for non-protocol therapy, PFS was 16.8 and 13.9 months, respectively; HR for PFS events, 0.72.

"The improvement as assessed by Independent Review Committee was statistically significant. Evaluation of biomarkers is ongoing to try to identify those patients who may benefit from first-line BEV-containing therapy for HER2-positive LR/mBC," the authors write.

Press Release
More Information

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events