View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, Dec. 12 (HealthDay News) -- Breast cancer survivors treated with chemotherapy plus radiation or radiation alone may experience poorer cognitive functioning over time, according to a study published online Dec. 12 in Cancer.
Kristin M. Phillips, Ph.D., from the Moffitt Cancer Center in Tampa, Fla., and colleagues investigated the influence of prior treatment on cognitive functioning in breast cancer survivors. The changes in cognitive functioning over time were compared for patients with stage 0 to II breast cancer who were treated with chemotherapy plus radiotherapy (CT group, 62 patients), or with radiotherapy alone (RT group, 67 patients), and for women with no cancer history (NC group, 184 women). Breast cancer survivors in both treatment arms underwent neuropsychological assessments at six and 36 months after treatment completion, and control group participants were assessed over a similar time interval.
The investigators found that a significant group × time effect existed in the processing speed domain that reflected a trend for improvement over time for the NC group, but not the RC or CT groups. A significant group effect was also seen for executive functioning, with better performance in the NC group than the CT and RT groups. Additional analyses did not yield an association for the administration of hormonal therapy with changes in cognitive functioning over time.
"Future research should seek to examine possible mechanisms that could explain the apparent prolonged impact of both chemotherapy and radiotherapy on cognitive functioning in breast cancer survivors," the authors write.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top