Combo Therapies in Psoriasis More Effective Than Monotherapy

Adding phototherapy to topical monotherapy improves psoriasis clearance

MONDAY, Dec. 19 (HealthDay News) -- Many combination topical therapies for psoriasis are more effective than topical monotherapies, and adding phototherapy to topical monotherapy generally improves psoriasis clearance, compared to monotherapy alone, according to a meta-analysis published online Dec. 19 in the Archives of Dermatology.

Elizabeth E. Bailey, M.D., M.P.H., from the Brigham and Women's Hospital in Boston, and colleagues reviewed available literature through July 2010 to evaluate the current state of evidence for combination topical and systemic therapies for mild to severe psoriasis. Randomized controlled trials were included in the meta-analysis if data were available regarding the proportion of disease clearance or mean change in clinical severity score for combination treatment efficacy, compared with one or more monotherapies. Data were extracted for clearance, definition of clearance, mean and standard deviations for baseline and final disease symptom scores, and major design characteristics.

The investigators found that, compared to one or more monotherapies, the likelihood of disease clearance was greater with combination regimens of: vitamin D derivative with corticosteroid or ultra violet (UV)-B; vitamin A derivative combined with psoralen-UV-A or corticosteroid or UV-B; and corticosteroid combined with hydrocolloid occlusion dressings, UV-B and alefacept, and vitamins A and D derivatives. Significant sources of heterogeneity between the studies were the blinding status and potency of the corticosteroid treatments used.

"Future research in combination therapy is necessary to devise new therapeutic strategies to maximize efficacy while minimizing adverse effects," the authors write.

One author disclosed financial ties to Amgen, Abbott, and Janssen Biotech, which manufacture psoriasis treatment products.

Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95

Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95

Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events