Biomarker Patterns Indicative of Weight Loss Benefits

Biomarkers reveal cumulative health benefits of dieting despite partial weight regain

MONDAY, Jan. 9 (HealthDay News) -- Biomarker patterns reflect both the short-term benefits of weight reduction and the long-term cumulative benefits of healthful eating, despite partial weight regain, according to a study published online Dec. 21 in Diabetes Care.

Matthias Blüher, M.D., from the University of Leipzig in Germany, and colleagues analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the Dietary Intervention Randomized Controlled Trial. The trial consisted of a two-year diet intervention, using low-fat, Mediterranean, or low-carbohydrate diets for weight loss.

The researchers identified two distinct biomarker patterns: pattern A, which tightly corresponded to changes in body weight, and pattern B, which displayed a continued, cumulative improvement compared with baseline throughout the intervention. In pattern A, biomarkers (including insulin, triglycerides, leptin, chemerin, monocyte chemoattractant protein 1, and retinol binding protein 4) measured during the weight loss phase (zero to six months) trended in the opposite direction during the weight maintenance/regain phase (seven to 24 months). Pattern B biomarkers (including high molecular weight adiponectin, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, fetuin-A, progranulin, and vaspin) showed an ongoing and cumulative improvement throughout the intervention. Although the magnitude of change varied, both patterns were consistent across sex, type 2 diabetes groups, and diet groups.

"In conclusion, we demonstrate for the first time that two major classes of dynamics of biomarkers can be described during long-term diet interventions," the authors write. "One pattern closely reflects weight change, and the other is suggestive of cumulative beneficial effects, alternatively as a delayed response to the initial weight loss or perhaps to continued healthful dieting."

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