View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Jan. 4 (HealthDay News) -- For young children, 12-week prophylactic treatment with montelukast does not reduce the incidence of upper respiratory tract infections (URIs), according to a study published online Jan. 4 in Pediatrics.
Eran Kozer, M.D., from the Assaf Harofeh Medical Center in Zerifin, Israel, and colleagues investigated whether prophylactic treatment with montelukast reduces the incidence and severity of URI in children. A total of 300 healthy children (aged 1 to 5 years), with no previous history of reactive airway disease, were randomly assigned to receive montelukast (153 children) or a look-alike placebo (147 children) for 12 weeks. Of these, 131 children in the montelukast group, and 129 in the placebo group, completed the 12-week treatment. Parents of recruited children recorded any acute symptoms of URI in their children, and were contacted once a week to collect information regarding the occurrence of acute respiratory episodes. The number of URI episodes was the primary outcome measure.
The investigators found that the number of weeks in which URI was reported was 30.4 and 30.7 percent in children treated with montelukast and placebo, respectively. None of the secondary variables showed any significant difference between the groups.
"In preschool-aged children, 12-week treatment with montelukast, compared with placebo, did not reduce the incidence of URI," the authors write.
Several authors disclosed financial ties to Merck Sharp & Dohme Israel, which partially funded the study and manufactures montelukast.
Full Text (subscription or payment may be required)
Find in-depth content on major issues provided by leading companies in partnership with NursingCenter.com
BD Safety Beyond Needlestick Prevention Learning Center
Sponsored by BD Medical
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top