Maternal Antidepressants Up Infant Pulmonary Hypertension

Similar risk found across the selective serotonin reuptake inhibitor class of antidepressants

FRIDAY, Jan. 13 (HealthDay News) -- Use of antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), during pregnancy increases the risk of persistent pulmonary hypertension in newborns, according to a study published online Jan. 12 in BMJ.

To assess whether the use of SSRIs during pregnancy increased the risk of persistent pulmonary hypertension in newborns, Helle Kieler, M.D., Ph.D., of the Karolinska Institute in Stockholm, Sweden, and colleagues evaluated data from the national health registers of the five Nordic countries. Data from more than 1.6 million infants (born after gestational week 33) were included in the study.

The researchers found that 30,000 women had used SSRIs during pregnancy from 1996 to 2007, and that 11,014 had been prescribed an SSRI after gestational week 20. Exposure to SSRIs in late pregnancy was associated with an increased risk of persistent pulmonary hypertension in the newborn, with an absolute risk of three per 1,000 liveborn infants when compared with the background incidence of 1.2 per 1,000 (adjusted odds ratio [OR]; 2.1, 95 percent confidence interval [CI], 1.5 to 3.0). The increased risks for each of the specific SSRIs (sertraline, citalopram, paroxetine, and fluoxetine) were similar in magnitude. Filling a prescription for SSRIs before gestational week eight was associated with slightly increased risks (adjusted OR, 1.4; 95 percent CI, 1.0 to 2.0).

"The risk of persistent pulmonary hypertension of the newborn is low, but use of SSRIs in late pregnancy increases that risk more than two-fold. The increased risk seems to be a class effect," write the authors.

The study was funded by the Swedish Pharmacy Company.

Full Text
Editorial

Copyright © 2012 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events